Capsaicin Cream

What Is Capsaicin?

Capsaicin is the compound that makes chili peppers hot. When applied topically, it can help reduce pain by affecting pain-signaling nerve fibers in the skin. Available in creams, gels, and patches, capsaicin is used for various chronic pain conditions. It works differently than other pain relievers.¹

How It Works²

Binds to TRPV1 receptors on nerve fibers
Initially causes burning sensation
With repeated use, depletes substance P
Desensitizes pain fibers over time
Reduces pain signal transmission

Available Forms

OTC Creams (Low Concentration)

0.025% - 0.1% capsaicin
Applied 3-4 times daily
Several weeks for full effect

Prescription Patch (High Concentration)

8% capsaicin (Qutenza)
Applied by healthcare provider
Single application lasts weeks/months
For postherpetic neuralgia

Conditions Treated

Postherpetic neuralgia (shingles pain)
Diabetic neuropathy
Osteoarthritis
Rheumatoid arthritis
Muscle pain
Back pain

How to Use³

Apply thin layer to affected area
Wash hands thoroughly after
Keep away from eyes and mucous membranes
Use consistently for best results
May take 2-4 weeks for full effect

The Burning Sensation

Burning, stinging is expected initially
Usually decreases with continued use
Part of how it works
Start with lower concentration
Most people tolerate it

Tips for Tolerating

Start with less frequent application
Use small amount
Apply to smaller area first
Expect 1-2 weeks of burning
Don't apply to broken skin

Side Effects

Burning, stinging (most common)
Redness at application site
Usually local effects only
Rarely causes allergic reaction

Precautions

Avoid eyes, nose, mouth
Don't bandage tightly over it
Don't use with heating pad
Wash hands well (or use gloves)
Don't use on broken skin

References

Derry S, Rice AS, Cole P, et al. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017;1:CD007393.
Anand P, Bley K. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth. 2011;107(4):490-502.
Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 2004;328(7446):991.