Diabetic Neuropathy

What Is Diabetic Neuropathy?

Diabetic neuropathy is nerve damage caused by high blood sugar levels over time. It affects up to 50% of people with diabetes. The most common form affects the feet and legs, but it can affect nerves throughout the body.¹

Types²

Peripheral neuropathy - Feet, legs, hands, arms (most common)
Autonomic neuropathy - Internal organs
Proximal neuropathy - Hips, thighs, buttocks
Focal neuropathy - Single nerves

Symptoms of Peripheral Neuropathy

Numbness or reduced sensation
Tingling or burning
Sharp or shooting pain
Extreme sensitivity to touch
Muscle weakness
Balance problems
Foot ulcers (from unnoticed injuries)

Prevention

Blood sugar control (most important)
Regular foot exams
Healthy lifestyle
Avoid smoking
Limit alcohol

Treatment³

Blood Sugar Management

Optimize glucose control
Can slow progression

Pain Medications

Duloxetine (FDA-approved)
Pregabalin (FDA-approved)
Gabapentin
Tricyclic antidepressants
Topical treatments

Foot Care

Daily foot inspections
Proper footwear
Regular podiatry visits

References

Pop-Busui R, Boulton AJ, Feldman EL, et al. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care. 2017;40(1):136-154.
Callaghan BC, Cheng HT, Stables CL, et al. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol. 2012;11(6):521-534.
Bril V, England J, Franklin GM, et al. Evidence-based guideline: treatment of painful diabetic neuropathy. Neurology. 2011;76(20):1758-1765.