Supplements for Pain
An overview of dietary supplements used for chronic pain
Understanding Supplements
Many people with chronic pain try dietary supplements. While some have evidence supporting their use, others have limited research. Supplements are not regulated like medications, so quality varies. Always discuss with your healthcare provider.1
Supplements with Some Evidence2
For Osteoarthritis
- Glucosamine/Chondroitin - Mixed evidence; may help some
- SAMe - May be comparable to NSAIDs
- Avocado-soybean unsaponifiables (ASU)
Anti-Inflammatory
- Omega-3 fatty acids - Modest anti-inflammatory effects
- Turmeric/Curcumin - Some evidence for OA
- Ginger - Modest evidence for OA
For Nerve Health
- Vitamin B12 - If deficient
- Alpha-lipoic acid - Diabetic neuropathy
For Muscle/Bone
- Vitamin D - If deficient
- Magnesium - May help muscle cramps
Important Considerations3
- Supplements aren't FDA-approved for treating disease
- Quality varies between brands
- Can interact with medications
- May have side effects
- "Natural" doesn't mean safe
- Cost can add up
Choosing Quality Products
- Look for third-party testing (USP, NSF, ConsumerLab)
- Choose reputable brands
- Be wary of exaggerated claims
- Check for drug interactions
Talk to Your Provider
- Before starting any supplement
- If you have health conditions
- If you take medications
- Before surgery (some need to stop)
References
- National Center for Complementary and Integrative Health. Using Dietary Supplements Wisely. NCCIH.NIH.gov. 2023.
- Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating symptoms of joint arthritis. J Med Food. 2016;19(8):717-729.
- Wandel S, Jüni P, Tendal B, et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee. BMJ. 2010;341:c4675.